| 2022/05/07 | Cruz Azul |  | 1-1 (3-1 pen.) |  | Necaxa | ||||
| 2022/05/08 | Monterrey |  | 2-2 (1-3 pen.) |  | Atlético San Luis | ||||
| Puebla |  | 2-2 (3-1 pen.) |  | Mazatlán | |||||
| 2022/05/09 | Chivas |  | 4-1 |  | Pumas |
| 2 |
|
André-Pierre Gignac Tigres | 14 G |
| 3 |
|
Julián Quiñones Atlas | 9 G |
| 3 |
|
Rodrigo Aguirre Necaxa | 9 G |
| 5 |
|
Germán Berterame Atlético San Luis | 8 G |
