| Total | 143 | 40 | (28%) | 38 | (27%) | 65 | (45%) |
| Casa | 72 | 27 | (38%) | 20 | (28%) | 25 | (35%) |
| Fuera | 71 | 13 | (18%) | 18 | (25%) | 40 | (56%) |
D | 2023-08-08 | Plymouth Argyle |  | 2-0 |  | Leyton Orient | 1R | ||
D | 2022-08-09 | Forest Green Rovers |  | 2-0 | | Leyton Orient | 1R | ||
E | 2021-08-11 | Leyton Orient | | 1-1(3-5 pen.) |  | QPR | 1R | ||
E | 2020-09-22 | Leyton Orient | | 0-0 |  | Tottenham | 3R | ||
V | 2020-09-15 | Leyton Orient | | 3-2 | | Plymouth Argyle | 2R | ||
V | 2020-09-05 | Forest Green Rovers | | 1-2 | | Leyton Orient | 1R | ||
D | 2019-08-13 | Plymouth Argyle | | 2-0 | | Leyton Orient | 1R | ||
D | 2016-08-09 | Leyton Orient | | 2-3 |  | Fulham | 1R | ||
D | 2015-08-11 | MK Dons |  | 2-1 | | Leyton Orient | 1R | ||
D | 2014-09-23 | Leyton Orient | | 0-1 |  | Sheffield United | 3R | ||
V | 2014-08-27 | Aston Villa |  | 0-1 | | Leyton Orient | 2R | ||
E | 2014-08-12 | Plymouth Argyle | | 3-3(5-6 pen.) | | Leyton Orient | 1R | ||
D | 2013-08-27 | Leyton Orient | | 0-1 |  | Hull City | 2R | ||
V | 2013-08-06 | Leyton Orient | | 3-2 |  | Coventry City | 1R | ||
D | 2012-08-29 | Everton |  | 5-0 | | Leyton Orient | 2R | ||
E | 2012-08-14 | Charlton Athletic |  | 1-1(3-4 pen.) | | Leyton Orient | 1R | ||
D | 2011-09-20 | Blackburn Rovers |  | 3-2 | | Leyton Orient | 3R | ||
V | 2011-08-30 | Leyton Orient | | 3-2 |  | Bristol Rovers | 2R | ||
E | 2011-08-09 | Southend United |  | 1-1(3-4 pen.) | | Leyton Orient | 1R | ||
D | 2010-08-24 | Leyton Orient | | 0-2 |  | West Bromwich | 2R |
