| 2021/09/29 | APEJES Mfou |  | 1-3 |  | Cotonsport |
| 2021/09/29 | Fortuna Yaoundé |  | 5-0 |  | Fovu |
| 2021/09/19 | Eding Sport |  | 3-2 |  | Tonnerre Yaoundé |
| 2021/09/19 | Fortuna Yaoundé | | 1-2 | | APEJES Mfou | ||||
| 2021/09/23 | Cotonsport | | 0-0 (5-4 pen.) | | Fovu |
| P | GM | GR | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Fortuna Yaoundé | 20 | 29 | 17 | 39 |
| 2 | | Fovu | 20 | 32 | 21 | 36 |
| 3 |  | Stade Renard | 20 | 22 | 11 | 36 |
| 4 |  | Bamboutos | 20 | 28 | 18 | 35 |
| 5 |  | PWD | 20 | 22 | 14 | 33 |
| 6 |  | Stade Bandjoun | 20 | 23 | 23 | 24 |
| 7 |  | Avion Academy | 20 | 19 | 21 | 23 |
| 8 | | Eding Sport | 20 | 22 | 26 | 22 |
| 9 |  | Union Douala | 20 | 11 | 22 | 18 |
| 10 |  | Dragon Club | 20 | 22 | 35 | 16 |
| 11 |  | Yafoot | 20 | 12 | 34 | 10 |
| P | GM | GR | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Cotonsport | 18 | 32 | 13 | 32 |
| 2 |  | Young Sport Academy | 18 | 24 | 13 | 27 |
| 3 |  | Canon Yaoundé | 18 | 18 | 15 | 27 |
| 4 | | APEJES Mfou | 18 | 18 | 17 | 27 |
| 5 |  | UMS de Loum | 18 | 13 | 11 | 25 |
| 6 |  | Colombe Sportive | 18 | 21 | 20 | 23 |
| 7 | | Tonnerre Yaoundé | 18 | 15 | 20 | 21 |
| 8 |  | Astres | 18 | 13 | 19 | 21 |
| 9 |  | Panthère FC | 18 | 18 | 25 | 21 |
| 10 |  | New Star Douala | 18 | 11 | 30 | 16 |
